Abstract. REIS JR., J.L.; SILVA, F.L.; RACHID, M.A. and NOGUEIRA, R.H.G.. Renal amyloidosis in a Shar-Pei dog: A case report. Arq. Bras. Med. Vet. Zootec. Imagem da capa: A amiloidose ocorre frequentemente em indivíduos de meia- idade ou . crônicas ou de diálise renal de longo prazo. A maioria dos casos. Bakris GL, Williams M, Dworkin L, et al: Preserving renal function in adults Am J Kidney Dis , sentarão amiloidose na biópsia renal(1).

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Pediatr Nephrol ; 26 8: Six patients had unequivocal hereditary amyloidosis. Secondary amyloidosis associated with tuberculosis in renal biopsy.

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Swiss Med Wkly ; Currently, amyloid deposits are identified on the basis of their apple-green birefringence under polarized light microscopy in Congo red stained histological preparations, the gold standard for amyloid detection, and the presence of rigid, non-branching fibrils 7. But, among us, chronic infectious disorders are still the most frequent cause of AA amyloidosis, mainly pulmonary tuberculosis, which is according to the fact that Portugal still has one of the highest tuberculosis incidence rates in European Union countries Commonly, paraffin-embedded tissue is used for the typing of amyloid by immunohistochemistry.

High prevalence of hypertension among AFib patients may be secondary to chronic kidney disease, but direct amyloid deposition in vascular walls may also be involved Recently, pictures of senile amyloidosis have been described in patients with HFpEF, demonstrating the need for clinical cardiologists to investigate this etiology in suspect cases. Amyloid ; 13 Suppl amiliidose Renal transplantation in systemic amyloidosis-importance of amyloid fibril type and precursor protein abundance.


Orphanet: Amiloidose

Nevertheless, the treatment for pulmonary TB was started. DNA analysis should always be considered if hereditary amyloidosis is suspected.

AL-amyloidosis is underdiagnosed in renal biopsies. Nephrotic syndrome was the most frequent clinical manifestation, independently of the amyloid type.

AA amyloidosis, in our series, affected younger individuals, which may be related to early beginning of most of the underlying conditions, mainly infectious and inflammatory diseases, and therapeutic failures at suppressing inflammation. When we compare our results with those, our first conclusion is that we need to raise our spectrum of amyloid antibodies with the inclusion of anti-LECT2, anti-Apo A-IV and anti-Ig heavy chain as a way to reduce unclassified cases.

Am J Surg Pathol ; 27 4: Selection bias of data from tertiary centres becomes potentially unrepresentative 1, All the immunohistochemistry slides were reviewed by a pathologist and a nephrologist with expertise in amyloid nephropathy.

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Nephrol Dial Transplant ; 19 Amyloid ; 11 1: These limitations are particularly evident in the cases of AL and hereditary amyloidosis. Nature ; N Engl J Med ; All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Porto University Medical Dissertation ; Fevers, genes, and innate immunity. Mean age at diagnosis was Diagnostic methods Its diagnosis is based on histological findings. For each patient, data was obtained from retrospective review of medical records: Variant apolipoprotein AI as a major constituent of a human hereditary amyloid.


The clinical suspicion of amyloidosis should be increased in cases of HFPS where the cardio imaging methods are compatible with infiltrative cardiomyopathy. Finally, for amyloidosis due to deposits of transthyretin, which is produced in the liver, liver transplant has been suggested to stop the production of the causative protein.

Cardiac Amyloidosis and its New Clinical Phenotype: Heart Failure with Preserved Ejection Fraction.

Immunohistochemical identification of the chemical type of amyloid is still the first step in classifying amyloid Early diagnosis and rapid control of the underlying inflammatory or infectious disease are of the utmost importance to prevent irreversible organ damage The type of protein could not be classified in 12 Blood ; 9: Auto-inflammatory diseases are now the most common cause of AA amyloidosis in children, and paediatric nephrologists should be aware that renal amyloidosis is potentially preventable in these conditions ATTR amyloidosis was identified only in two cases, what was expected since this study was performed outside the referral centre for the disease in northern Portugal.

Amyloidoses are a group of heterogeneous diseases classified according to the nature of their causative amyloid proteins. A total of consecutive patients with different types of amyloidoses were included. Pathophysiology and treatment of systemic amyloidosis.